High oxidative damage levels in the longest-living rodent, the naked mole-rat
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چکیده
منابع مشابه
CALL FOR PAPERS Cardiovascular Aging Vascular aging in the longest-living rodent, the naked mole rat
Csiszar A, Labinskyy N, Orosz Z, Xiangmin Z, Buffenstein R, Ungvari Z. Vascular aging in the longest-living rodent, the naked mole rat. Am J Physiol Heart Circ Physiol 293: H919–H927, 2007. First published April 27, 2007; doi:10.1152/ajpheart.01287.2006.— The naked mole rat (NMR; Heterocephalus glaber) is the longestliving rodent known [maximum lifespan potential (MLSP): 28 yr] and is a unique ...
متن کاملVascular aging in the longest-living rodent, the naked mole rat.
The naked mole rat (NMR; Heterocephalus glaber) is the longest-living rodent known [maximum lifespan potential (MLSP): >28 yr] and is a unique model of successful aging showing attenuated declines in most physiological function. This study addresses age-related changes in endothelial function and production of reactive oxygen species in NMR arteries and vessels of shorter-living Fischer 344 rat...
متن کاملProtein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.
The widely accepted oxidative stress theory of aging postulates that aging results from accumulation of oxidative damage. Surprisingly, data from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP) > 28.3 years], when compared with mice (MLSP 3.5 years) exhibit higher levels of lipid peroxidation, protein carbonylation, and DNA oxidative damage even at a yo...
متن کاملComparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice.
Vascular aging is characterized by decreased nitric oxide (NO) bioavailability, oxidative stress, and enhanced apoptotic cell death. We hypothesized that interspecies comparative assessment of vascular function among rodents with disparate longevity may offer insight into the mechanisms determining successful vascular aging. We focused on four rodents that show approximately an order of magnitu...
متن کاملExtended Postnatal Brain Development in the Longest-Lived Rodent: Prolonged Maintenance of Neotenous Traits in the Naked Mole-Rat Brain
The naked mole-rat (NMR) is the longest-lived rodent with a maximum lifespan >31 years. Intriguingly, fully-grown naked mole-rats (NMRs) exhibit many traits typical of neonatal rodents. However, little is known about NMR growth and maturation, and we question whether sustained neotenous features when compared to mice, reflect an extended developmental period, commensurate with their exceptional...
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ژورنال
عنوان ژورنال: Aging Cell
سال: 2006
ISSN: 1474-9718,1474-9726
DOI: 10.1111/j.1474-9726.2006.00237.x